Shubhasis Haldar

Associate Professor

Research Lab Webpage

Department of Chemical and Biological Sciences    

S.N. Bose National Centre for Basic Sciences,   Block JD, Sector III, Salt Lake, Kolkata - 700106
Telephone +91-33-2335 5706/07/08 (extn: 212)


Educational Background:

  • Ph.D, 2013- Single molecule Biophysics, Indian Institute of Chemical Biology

Professional Background:

  • Associate Professor (2023- till date) Department of Chemical and Biological Sciences, S.N. Bose National Centre, Kolkata, India

  • Tenured Associate Professor (2023-2023), Ashoka University, Sonipat, Haryana, 131029, India

  • Tenure track Assistant Professor (2018-2023), Ashoka University, Sonipat, Haryana, 131029, India

  • Postdoctoral fellow (2016 - 2018), Department of Biological Sciences, Columbia University, (Advisor: Julio Fernandez)

  • Postdoctoral fellow (2013-2015), Department of Cellular Biochemistry, Max Planck Institute of biochemistry, Munich- 82152 Germany (Advisor: Prof. Dr. Franz-Ulrich Hartl)

Main area of Research: Single molecule biophysics

Research Interests

  • Mechanical Roles of Chaperone-assisted Protein Folding.
  • Role of Mechanosensitive Proteins in Focal Adhesion-mediated Cellular Processes.
  • Mechanochemical Signaling in Neurodegenerative Pathologies.











































Significant Recent Publications: 

  • Chakraborty, S. & Haldar, S.* (2023) “Single-molecule covalent magnetic tweezers” Trends in Biochemical Sciences just accepted(Impact factor 14.3)

    * Corresponding author

  • Chakraborty, S., Chaudhuri, D., Banerjee, S., & Haldar, S.* (2022) “Direct observation of chaperone-modulated talin mechanics with single molecule resolution”  Communications Biology, 5(1),1-14(Impact factor 6.5)
  • Chakraborty, S., Chaudhuri, D., Chaudhuri, D., Singh, V., Banerjee, S., D. Chowdhury and Haldar, S.* (2022) “Connecting conformational stiffness of the protein with energy landscape by a single experiment” Nanoscale 14, 7659 - 73 (Impact factor 8.3)

    * Corresponding author
  • Chaudhuri, D., Banerjee, S., Chakraborty, S., & Haldar, S.* (2022) “Direct observation of the mechanical role of bacterial chaperones in protein folding” Biomacromolecules 23, 7, 2951–2967 (Impact factor 7)
  • * Corresponding author

  • Eckels, E.C., Chaudhuri, D., Chakraborty, S., Echelman, D., & Haldar, S.*, (2021) “DsbA is a redox-switchable mechanical chaperone” Chemical Sciences, 2021, 12, 11109-11120 (Impact factor 10)
  • * Corresponding authors.

  • Alonso-Caballero, A., Echelman, D., Tapia-Rojo, R., Haldar, S., Eckels, E. and Fernandez, J. (2020) “Protein folding modulates the adhesion strategy of Gram-positive pathogens” Nature Chemistry 13 (2), 172-181 (Impact factor 24.3)
  • Banerjee, S., Nara, R., Chakraborty, S., Chowdhury, D. & Haldar, S.* (2022) “Integrin regulated autoimmune disorders: Understanding the role of mechanical force in autoimmunity” Front. Cell Dev. Biol. 10:852878 (Impact factor 6.7)
  • * Corresponding author

  • Haldar, S.*, Tapia-Rojo, R., Eckels, E.C., Valle-Orero, J., & Fernandez, J.*, (2017) “Mechanical Folding by the Trigger Factor Chaperone” Nature Communications 8 (1): 668. (Impact factor 17.7)
  • * Corresponding author

  • Banerjee, S., Chakraborty, S., Sreepada,A., Banerji, D., Goyal, S., Khurana, Y. and Haldar, S.*, (2021) “Cutting-edge single molecule technologies unveil new mechanics in cellular biochemistry” Annual Reviews of Biophysics (Impact factor 19.8) 50, 419-445.
  • * Corresponding author

  • Eckels, E.#, Haldar, S.#, Rafael Tapia-Rojo, Rivas-Pardo, A., Fernández, J. "Disulfide bonds: the power switches of elastic proteins" (2019) Cell Reports, 6, 1836-1847 (Impact factor 10)
  • These authors contributed equally.


















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