M. Sc. Kalyani University
Ph.D, TIFR, Mumbai
Research Scientist, S.N. Bose National Centre for Basic Sciences
Assistant Professor, Department of Biological Sciences, IISER-Kolkata, India
Post-doctoral Associate, Laboratory of Structural Biology, NIEHS, National Institute of Health, NC, USA
Post-doctoral Fellow, Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada
Main area of work
My research interests, so far, have been driven by the quest of understanding the macromolecular basis in biological system by studying their structure and the correlation between structure and biochemical function.
Structural Characterization of Proteins and Nucleic Acids
NMR Spectroscopy of Biomolecules
Protein-DNA, Protein-Protein and Protein-Ligand interactions
Significant recent publications:
Marika Midon, Patrick Schaefer, Alfred Pingoud,
Mahua Ghosh, Andrea Moon, Matthew Cuneo, Robert. E. London and Gregor Meiss Mutational and biochemical analysis of the DNA-entry nuclease EndA from Streptococcus pneumonia. Nucleic Acids Res., 2010, 36(12),4032-4037.
Jana Kieper, Christiane Lauber, Oleg Gimadutdinow, Anna Urbanska, Iwona Cymerman,
Mahua Ghosh, Bartosz Szczesny, and Gregor Meiss, Production and characterization of recombinant protein preparations of Endonuclease G-homologs from yeast, C. elegans and humans, Protein ExprPurif, 2010, 73(1), 99-106.
Geoffrey A. Mueller Matthew Miller, Eugene F. DeRose, Mahua Ghosh, Robert E. London, Traci T. M. Hall, NMR Structural Characterization of DROSHA: a micro RNA binding protein, Silence, 2010, 1:2, 1-5.
Wilton, David; Ghosh, Mahua; Chary, Kandala; Akasaka, Kazuyuki Williamson, Mike, Structural change in a B-DNA helix with hydrostatic pressure, Nucleic Acids Res., 2008, 36(12),4032-4037.
Mahua Ghosh,Gregor Meiss, Alfred Pingoud, Robert E. London and Lars C. Pederson, The Nuclease A – inhibitor complex is characterized by a novel metal ion bridge, Journal of Biological Chemistry, 2007, 282(8), 5682-5690.
Mahua Ghosh, Gregor Meiss, Alfred Pingoud, Robert E. London and Lars C. Pederson,
Structural insights into the mechanism of nuclease A: a ββα metal nuclease from Anabaena, Journal of Biological Chemistry, 2005, 280(30), 27990-27997.